Microbiologist (born 1931) who won the 1978 Nobel Prize in Physiology or Medicine for the discovery of restriction enzymes and their application to problems of molecular genetics. Handwritten manuscript, titled and signed at the top, “Molecular basis of restriction and modification in bacteria, Hamilton O. Smith, Dept of Mol. Biol & Genetics, JHU Medical School,” five pages, 8.5 x 11, circa 1984. In part: “There are only a limited number of ways for bacteria to protect themselves against viral attack. One way is by antigenic variation of surface receptors, thus assuming that some bacteria in the population will escape infection. Another very effective way is by restriction and modification of DNA.” Includes a 1984 ALS transmitting the manuscript, describing it as “the first draft of an abstract…for a lecture I am to deliver,” signed, “Hamilton O. Smith.” In fine condition. Pre-certified PSA/DNA.
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