Canadian physician and researcher (1891–1941) who shared the 1923 Nobel Prize in Medicine for his role in the discovery of insulin. Rare ALS signed “Fred,” one page both sides, 5 x 3.5, no date. Letter to “Beulah.” In part: “Your clever & charming letter was most gratefully received. I have been closely guarded since I saw you last for at that time I was having a flare up of my appendix & had to go to bed every night at 7:30 for ten days before the opening. And since—well you know what it has been like. As far as the operation goes there was nothing to it. I had a very easy time.” In fine condition, with some trivial soiling to the borders. RR Auction COA.