Iconic concocter and shrewd marketer (1819-1883) of a commercially successful herbal-alcoholic ‘women's tonic’ meant to relieve menstrual and menopausal pains. ALS, one page, lightly-lined, 7.5 x 9.75, April 5, 1880. Pinkham writes Carrie Melville of Topsfield, Massachusetts, with advice. In part: “My Veg. Comp. is just what you need; it is especially adapted to the period termed ‘the turn of life.’ It is composed of roots & herbs. If you are constipated take my Liver Pills according to the directions and after the third dose commence taking comp. For piles—chop fine a piece of of tobacco two thirds the size of our three fingers and simmer in two table spoonfulls [sic] of lard twelve hours, then strain, and apply at night on a soft linen rag. So manage your diet as to have a passage from your bowels daily; my Liver Pills will assist if necessary. They are not intended for a cathartic but to quicken the liver & help one to have a regular discharge. After using these remedies two or three weeks please write me of their effect.” Intersecting horizontal and vertical folds, some brushes and ink spots, and a few spots of toning, otherwise fine condition. Accompanied by the original mailing envelope. RRAuction COA.