Flown cover carried on the SpaceX Crew-5 mission to the International Space Station, signed in space in black ballpoint by the crews of Soyuz MS-22, Dragon Crew-5, and Dragon Crew-6, with the missions written by Anna Kikina. Signers are: Sergey Prokopyev, Dmitry Petelin, Francisco Rubio, Nicole Aunapu Mann, Josh A. Cassada, Koichi Wakata, Anna Kikina, Stephen Bowen, Warren Hoburg, Sultan Al Neyadi, and Andrey Fedyaev. The cover bears three on-board International Space Station stamps, including the postmark of the Russian segment of the ISS. In fine condition.