Dutch physical and organic chemist (1852–1911) and the first winner of the 1901 Nobel Prize in chemistry. ALS in German, signed “J. H. V. Hoff,” one page, 4.25 x 7, November 23, 1905. Crisply penned untranslated letter. Uniform block of toning over text and signature from envelope, with some light spotting over signature as well, otherwise fine condition. Accompanied by the original mailing envelope. RRAuction COA.