Born Giovanni Angelo Medici (1499-1565), was Pope from 1559 to 1565. He is notable for presiding over the culmination of the Council of Trent. LS in Italian, signed “El Card’le de Medici,” one page, 8.5 x 11.5, November 17, 1550. Letter written as the Archbishop of Ragusa to Signori Priore di Panore, requesting that Giuseppe Pallazzi be considered for a vacancy. Boldly signed at the conclusion. Integral second page bears two dockets in another hand, as well as the intact paper seal. Several small pinholes to page, previous storage folds, and a bit of scattered light toning and soiling, otherwise fine condition. RRAuction COA.